import xlwings as xw
app = xw.App(visible=False)  # 隐藏Excel
wb = app.books.open('文档1.xlsx')  # 打开工作簿


sht = wb.sheets['Sheet1']  # 实例化工作表1

#获取行数和列数
rows_count=sht.range(1, 1).expand().shape[0]
cols_count=sht.range(1, 1).expand().shape[1]
print(rows_count,cols_count)

#获取指定单元格的内容
data = sht.range('C%s' %rows_count).value
print(data)

wb.close()
app.quit()